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KMID : 0370220110550020116
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Yakhak Hoeji
2011 Volume.55 No. 2 p.116 ~ p.120
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Inhibitory Effects of A-8 on Abnormal Rat Aortic Vascular Smooth Muscle Cell Proliferation
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Lim Yong
Lee Mi-Yea
Munkhtsetseg Tudev
Park Eun-Seok
Jung Jae-Kyeong
Yun Yeo-Pyo
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Abstract
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Abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression of proliferative cardiovascular diseases, including hypertension and atherosclerosis. To find antiproliferative agent (A)-8 had inhibitory effect on VSMCs proliferation. Therefore, we examined the antiproliferative effect of A-8, a newly synthesized obovatol derivative. To investigate the antiproliferative effect of A-8, we examined cell counting and [³H]-thymidine incorporation assays. The pre-incubation of A-8 (1~4 ㎛) significantly inhibited proliferation and DNA synthesis of 5% fetal bovine serum (FBS)-stimulated rat aortic VSMCs in concentration-dependent manner. Whereas, A-8 did not show any cytotoxicity in rat aortic VSMCs in this experimental condition by WST-1 assay. In addition, A-8 significantly inhibited 5% FBS-induced cell cycle progression in rat aortic VSMCs. These results show that A-8 may be developed as a potential antiproliferative agent for treatment of angioplasty restenosis and atherosclerosis. Furthermore, A-8 should be examined for further clinical application either as a single agent or in combination with other angioplasty restenosis or atherosclerosis agents.
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KEYWORD
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atherosclerosis, smooth muscle cell, FBS, obovatol
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